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《医学前沿(英文)》 2015年 第9卷 第1期 页码 20-29 doi: 10.1007/s11684-014-0371-x
Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.
关键词: cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke
Regulation of T cell immunity by cellular metabolism
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 463-472 doi: 10.1007/s11684-018-0668-2
T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.
关键词: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
Parametric sensitivity analysis of cellular diaphragm wall
Xi CHEN, Wei XU
《结构与土木工程前沿(英文)》 2012年 第6卷 第4期 页码 358-364 doi: 10.1007/s11709-012-0177-3
关键词: cellular diaphragm wall sensitivity analysis optimization centrifuge model test
Liver cell therapies: cellular sources and grafting strategies
《医学前沿(英文)》 2023年 第17卷 第3期 页码 432-457 doi: 10.1007/s11684-023-1002-1
关键词: liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies
Optimization of Land-use Based on the Theory of Cellular Automata and Value of Ecosystem Services
Lian-fu Jiang,Guo-xian Xu,Hao Jiang
《工程管理前沿(英文)》 2014年 第1卷 第4期 页码 395-401 doi: 10.15302/J-FEM-2014058
关键词: Ecosystem service function optimization of land use Cellular Automata (CA)
《结构与土木工程前沿(英文)》 2021年 第15卷 第3期 页码 781-792 doi: 10.1007/s11709-021-0733-9
关键词: lightweight cellular concrete construction-induced damage freeze-thaw action microstructure degradation mechanism
Macro-architectured cellular materials: Properties, characteristic modes, and prediction methods
Zheng-Dong MA
《机械工程前沿(英文)》 2018年 第13卷 第3期 页码 442-459 doi: 10.1007/s11465-018-0488-8
Macro-architectured cellular (MAC) material is defined as a class of engineered materials having configurable cells of relatively large (i.e., visible) size that can be architecturally designed to achieve various desired material properties. Two types of novel MAC materials, negative Poisson’s ratio material and biomimetic tendon reinforced material, were introduced in this study. To estimate the effective material properties for structural analyses and to optimally design such materials, a set of suitable homogenization methods was developed that provided an effective means for the multiscale modeling of MAC materials. First, a strain-based homogenization method was developed using an approach that separated the strain field into a homogenized strain field and a strain variation field in the local cellular domain superposed on the homogenized strain field. The principle of virtual displacements for the relationship between the strain variation field and the homogenized strain field was then used to condense the strain variation field onto the homogenized strain field. The new method was then extended to a stress-based homogenization process based on the principle of virtual forces and further applied to address the discrete systems represented by the beam or frame structures of the aforementioned MAC materials. The characteristic modes and the stress recovery process used to predict the stress distribution inside the cellular domain and thus determine the material strengths and failures at the local level are also discussed.
关键词: architectured material cellular materials multi-scale modeling homogenization method effective material properties computational method
A review of intelligent optimization for group scheduling problems in cellular manufacturing
《工程管理前沿(英文)》 页码 406-426 doi: 10.1007/s42524-022-0242-0
关键词: cellular manufacturing group scheduling flowshop literature review
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
《医学前沿(英文)》 2010年 第4卷 第3期 页码 290-293 doi: 10.1007/s11684-010-0093-7
关键词: breast cancer postmenopausal hormone therapy unopposed estrogen therapy combined estrogen-progestin therapy
Vaibhav Mundra, Ram I. Mahato
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 387-404 doi: 10.1007/s11705-014-1457-3
关键词: nanocarrier cellular uptake endosomal release nucleic acid drug
Jadav Chandra DAS,Debashis DE
《信息与电子工程前沿(英文)》 2016年 第17卷 第3期 页码 224-236 doi: 10.1631/FITEE.1500079
关键词: Quantum-dot cellular automata (QCA) Parity generator Parity checker Feynman gate Nanocommunication Power dissipation
Tangchun Wu
《医学前沿(英文)》 2020年 第14卷 第6期 页码 816-819 doi: 10.1007/s11684-020-0823-4
Functional role of ATM in the cellular response to DNA damage
Ming LIU, Wenxiang HU
《化学科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 179-187 doi: 10.1007/s11705-009-0268-4
关键词: ataxia-telangiectasia mutated (ATM) cell cycle checkpoint DNA damage signalling transduction
朱保平,马骞,刘凤玉
《中国工程科学》 2007年 第9卷 第6期 页码 43-47
提出了一种新的细胞自动机———二维可控细胞自动机。根据二维可控细胞自动机的性质,提出了一 种具有梯型结构的二维可控细胞自动机的伪随机序列发生方法。计算机模拟表明,具有梯型结构的二维可控细 胞自动机伪随机序列发生器实现简单,产生的序列具有速度高、统计特性好等优点。新的细胞自动机在对称密 码学中有广泛地应用。
Quality evaluation of lightweight cellular concrete by an ultrasound-based method
Xin LIU; Dongning SUN; Jinhe LIAO; Zhiwei SHAO; Yunqiang SHI; Siqing ZHANG; Yunlong YAO; Baoning HONG
《结构与土木工程前沿(英文)》 2022年 第16卷 第9期 页码 1170-1182 doi: 10.1007/s11709-022-0874-5
关键词: lightweight cellular concrete subgrade ultrasound testing quality evaluation crack discrimination
标题 作者 时间 类型 操作
Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
null
期刊论文
Optimization of Land-use Based on the Theory of Cellular Automata and Value of Ecosystem Services
Lian-fu Jiang,Guo-xian Xu,Hao Jiang
期刊论文
Influence of construction-induced damage on the degradation of freeze–thawed lightweight cellular concrete
期刊论文
Macro-architectured cellular materials: Properties, characteristic modes, and prediction methods
Zheng-Dong MA
期刊论文
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
期刊论文
Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic
Vaibhav Mundra, Ram I. Mahato
期刊论文
Quantum-dot cellular automata based reversible low power parity generator and parity checker design for
Jadav Chandra DAS,Debashis DE
期刊论文
Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
Tangchun Wu
期刊论文